The SA Greenberg Lab: The Inclusion Body Myositis Research Project

Dermatomyositis

We have several projects focused on understanding the mechanism of disease for dermatomyositis and developing therapy for it. Our dermatomyositis research has identified the presence in dermatomyositis muscle of immune cells specializing in the production of interferon-α. These cells are called plasmacytoid dendritic cells. Genes induced by interferon-α are highly active in dermatomyositis muscle. We believe that overactivation of this pathway is central to the injury to capillaries and muscle in this disease.

Our specific research projects in this area are:

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