Microarray technology allows for the parallel and high-throughput analysis of gene expression present in a biological sample, as reflected in the relative amounts of mRNA transcripts.
The development of this “genomic” technology was fostered by the Human Genome Project (1990-2003), and the explosive growth in available sequence data in databases like GenBank. This data has been used to manufacture microarrays in a process likened to downloading sequence databases onto chips.
A short PowerPoint presentation illustrating the basic principles of microarrays is available for download.
- Educational resources from Affymetrix
- Microarray Science Primer from the National Center for Biotechnology Information
- Children’s Hospital Informatics Program
- CHIP Textbook Microarrays for an Integrative Genomics