The SA Greenberg Lab: The Inclusion Body Myositis Research Project

Proteomics Technology

Mass spectrometry based proteomics is a revolutionary technology for the study of human disease. This technology has a wide-variety of applications. One of these applications is the high-throughput rapid and accurate identification of thousands of proteins present within a complex biological specimen.

Like microarray technology, proteomics offers an unbiased discovery approach to understanding diseased tissue. Proteomics, however, is in many ways a more subtle and powerful approach because of myriad possibilities for the fractionation of proteins prior to proteomic analysis and the capability of proteomics to study post-translational modification of proteins. For example, below is a figure demonstrating the detection of ubiquitinated ubiquitin in a muscle biopsy sample from a patient with inclusion body myositis.

The range of methods used for mass spectrometry based proteomics can be found in numerous medical publications.

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